Niu Qingbin, Zhu Jun, Yu Xingquan, Feng Tao, Ji Hong, Li Yuming, Zhang Weiwei, Hu Baoguang
Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, China.
Department of General Surgery, Boxing Hospital of Traditional Chinese, Binzhou, Shandong Province, China.
Gastroenterol Res Pract. 2020 Jan 28;2020:9342563. doi: 10.1155/2020/9342563. eCollection 2020.
() is the dominant member of the gastric microbiota and has infected more than half of the human population, of whom 5-15% develop gastric diseases ranging from gastritis and metaplasia to gastric cancer. These diseases always follow inflammation induced by cell surface and intracellular receptors and subsequent signaling, such as the NF-B pathway and inflammasomes. Some types of immune cells are recruited to enforce an antibacterial response, which could be impeded by virulence factors with or without a specific immune cell. Following decreased inflammation, neoplasm may appear with a little immune surveillance and may inhibit antitumor immunity. Therefore, the balance between -associated inflammation and anti-inflammation is crucial for human health and remains to be determined. Here, we discuss multiple inflammation and immunoregulatory cells in gastritis and summarize the main immune evasion strategies employed by gastric cancer.
（）是胃微生物群中的主要成员，已感染超过半数的人类，其中5%-15%会发展为从胃炎、化生到胃癌等各种胃部疾病。这些疾病总是伴随着由细胞表面和细胞内受体以及随后的信号传导（如NF-κB途径和炎性小体）诱导的炎症。一些类型的免疫细胞被招募来执行抗菌反应，而这种反应可能会受到有或没有特定免疫细胞的毒力因子的阻碍。炎症减轻后，肿瘤可能会在免疫监视较少的情况下出现，并可能抑制抗肿瘤免疫。因此，与（）相关的炎症和抗炎之间的平衡对人类健康至关重要，仍有待确定。在这里，我们讨论胃炎中的多种炎症和免疫调节细胞，并总结胃癌采用的主要免疫逃逸策略。
