Magyar Mate, Gonda Xenia, Pap Dorottya, Edes Andrea, Galambos Attila, Baksa Daniel, Kocsel Natalia, Szabo Edina, Bagdy Gyorgy, Elliott Rebecca, Kokonyei Gyongyi, Juhasz Gabriella
MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
Department of Neurology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Front Neurol. 2017 Jun 22;8:270. doi: 10.3389/fneur.2017.00270. eCollection 2017.
Migraine and depression frequently occur as comorbid conditions, and it has been hypothesized that migraine with and without depression may have a different genetic background. A distinct personality trait constellation has been described in migraineurs. Less attention, however, was paid to personality differences in migraineurs with and without depression which may also shed light on differences in the neurobiological, background. The aim of our study was to investigate big five personality traits, headaches, and lifetime depression (DEP) in a large European general population sample.
Relationship between DEP, Big Five Inventory personality traits, and headaches identified by the ID-Migraine Questionnaire were investigated in 3,026 individuals from Budapest and Manchester with multivariate and logistic regression analyses.
Both DEP and migraine(ID) showed differences in personality traits. Neuroticism was an independent risk factor for both conditions while a significant interaction effect appeared between the two in the case of openness. Namely, subjects with migraine(ID) and without DEP scored higher on openness compared to those who had depression.
While we confirmed previous results that high neuroticism is a risk factor for both depression and migraine, openness to experience was significantly lower in the co-occurrence of migraine and depression. Our results suggest that increased openness, possibly manifested in optimal or advantageous cognitive processing of pain experience in migraine may decrease the risk of co-occurrence of depression and migraine and thus may provide valuable insight for newer prevention and intervention approaches in the treatment of these conditions.
偏头痛和抑郁症经常作为共病出现，并且据推测，伴有和不伴有抑郁症的偏头痛可能具有不同的遗传背景。偏头痛患者中已经描述了一种独特的人格特质组合。然而，对于伴有和不伴有抑郁症的偏头痛患者的人格差异关注较少，而这些差异也可能有助于揭示神经生物学背景的差异。我们研究的目的是在一个大型欧洲普通人群样本中调查大五人格特质、头痛和终生抑郁症（DEP）情况。
采用多变量和逻辑回归分析，对来自布达佩斯和曼彻斯特的3026名个体进行研究，调查DEP、大五人格问卷中的人格特质与通过ID-偏头痛问卷确定的头痛之间的关系。
DEP和偏头痛（ID）在人格特质方面均表现出差异。神经质是这两种情况的独立危险因素，而在开放性方面两者之间出现了显著的交互作用。也就是说，与患有抑郁症的人相比，患有偏头痛（ID）但没有DEP的受试者在开放性方面得分更高。
虽然我们证实了之前的结果，即高神经质是抑郁症和偏头痛的危险因素，但在偏头痛和抑郁症同时出现时，开放性体验显著降低。我们的结果表明，开放性增加，可能表现为对偏头痛疼痛体验的最佳或有利认知加工，可能会降低抑郁症和偏头痛同时出现的风险，从而可能为这些疾病治疗中的新预防和干预方法提供有价值的见解。
