Ronald James, Davis Seth J
Department of Biology, University of York, York, YO10 5DD, UK.
F1000Res. 2017 Jun 21;6:951. doi: 10.12688/f1000research.11319.1. eCollection 2017.
Circadian clocks are molecular timekeepers that synchronise internal physiological processes with the external environment by integrating light and temperature stimuli. As in other eukaryotic organisms, circadian rhythms in plants are largely generated by an array of nuclear transcriptional regulators and associated co-regulators that are arranged into a series of interconnected molecular loops. These transcriptional regulators recruit chromatin-modifying enzymes that adjust the structure of the nucleosome to promote or inhibit DNA accessibility and thus guide transcription rates. In this review, we discuss the recent advances made in understanding the architecture of the oscillator and the chromatin dynamics that regulate the generation of rhythmic patterns of gene expression within the circadian clock.
生物钟是分子计时器，通过整合光和温度刺激，使内部生理过程与外部环境同步。与其他真核生物一样，植物中的昼夜节律很大程度上是由一系列核转录调节因子和相关的共调节因子产生的，这些因子排列成一系列相互连接的分子环。这些转录调节因子招募染色质修饰酶，这些酶会调整核小体的结构，以促进或抑制DNA的可及性，从而指导转录速率。在这篇综述中，我们讨论了在理解生物钟振荡器的结构以及调节生物钟内基因表达节律模式产生的染色质动力学方面取得的最新进展。
