Gregor Mendel Institute, Vienna Biocenter, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Gregor Mendel Institute, Vienna Biocenter, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
Biochim Biophys Acta Gene Regul Mech. 2017 Jan;1860(1):123-130. doi: 10.1016/j.bbagrm.2016.07.002. Epub 2016 Jul 10.
Chromatin based organization of eukaryotic genome plays a profound role in regulating gene transcription. Nucleosomes form the basic subunits of chromatin by packaging DNA with histone proteins, impeding the access of DNA to transcription factors and RNA polymerases. Exchange of histone variants in nucleosomes alters the properties of nucleosomes and thus modulates DNA exposure during transcriptional regulation. Growing evidence indicates the important function of histone variants in programming transcription during developmental transitions and stress response. Here we review how histone variants and their deposition machineries regulate the nucleosome stability and dynamics, and discuss the link between histone variants and transcriptional regulation in plants. This article is part of a Special Issue entitled: Plant Gene Regulatory Mechanisms and Networks, edited by Dr. Erich Grotewold and Dr. Nathan Springer.
真核生物基因组的染色质结构在调节基因转录中起着深远的作用。核小体通过用组蛋白包装 DNA 形成染色质的基本亚基，阻碍 DNA 与转录因子和 RNA 聚合酶的接触。核小体中组蛋白变体的交换改变了核小体的性质，从而在转录调控过程中调节 DNA 的暴露。越来越多的证据表明，组蛋白变体在发育转变和应激反应过程中对转录的编程中起着重要作用。在这里，我们回顾了组蛋白变体及其沉积机制如何调节核小体的稳定性和动力学，并讨论了组蛋白变体与植物中转录调控之间的联系。本文是由 Erich Grotewold 博士和 Nathan Springer 博士编辑的特刊“植物基因调控机制和网络”的一部分。
