Bai Xue, Harris Ashley D, Gong Tao, Puts Nicolaas A J, Wang Guangbin, Schär Michael, Barker Peter B, Edden Richard A E
Department of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Open J Radiol. 2017 Mar;7(1):35-44. doi: 10.4236/ojrad.2017.71004. Epub 2017 Mar 24.
The purpose of the present study was to assess the reproducibility of voxel placement for GABA-edited MRS. GABA-edited MRS data were acquired in 13 healthy volunteers from (3 cm) voxel; and within the same session a second acquisition was independently prescribed. A three-dimensional voxel mask image was reconstructed in T1-image-space using the SVMask tool (in house software). Reproducibility of voxel placement was assessed using the Dice overlap coefficient, both within-subject and between-subject following co-registration of T1 images and transformation of voxel mask images to standard space. Within-subject overlap coefficients were 86% ± 5%. Between-subject overlap coefficients were 75% ± 10%. For the two voxel locations considered (occipital and sensorimotor), voxel overlap was very similar. Between-subject values are higher due to between-session effects, anatomical variability and volume mismatch in standard space. While surprisingly low in terms of volume overlap, the overlap coefficients correspond to acceptable linear displacements.
本研究的目的是评估用于GABA编辑磁共振波谱（MRS）的体素放置的可重复性。在13名健康志愿者中采集了来自（3厘米）体素的GABA编辑MRS数据；并且在同一会话中独立规定了第二次采集。使用SVMask工具（内部软件）在T1图像空间中重建三维体素掩码图像。在T1图像配准以及体素掩码图像转换到标准空间后，使用骰子重叠系数评估体素放置的可重复性，包括受试者内和受试者间的评估。受试者内重叠系数为86%±5%。受试者间重叠系数为75%±10%。对于所考虑的两个体素位置（枕叶和感觉运动区），体素重叠非常相似。受试者间的值由于会话间效应、解剖变异性和标准空间中的体积不匹配而更高。虽然在体积重叠方面出奇地低，但重叠系数对应于可接受的线性位移。
