Tong Jiefeng, Hu Renjian, Zhao Yingying, Xu Yang, Zhao Xiaoying, Jin Xiuming
Hematology Department, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Med (Lausanne). 2017 Jun 22;4:67. doi: 10.3389/fmed.2017.00067. eCollection 2017.
Allogeneic hematopoietic stem cell transplantation (HSCT) is a well-established therapeutic option for a range of inherited and acquired hematological disorders. However, graft-versus-host disease (GVHD) remains the leading cause of non-relapse mortality in allogeneic HSCT recipients. Ocular involvement occurs in up to 80% of chronic GVHD patients. In our cases, the diagnosis of vitamin A deficiency was suspected for GVHD patients. Serum vitamin A measurements were conducted to confirm clinical suspicions. Our study revealed significant decrease in serum levels of vitamin A in chronic liver GVHD patients. Although there have been many studies evaluating ocular manifestations in patients with GVHD, the present study is, to our knowledge, the first to study the relationship between vitamin A and ocular manifestations of GVHD in humans. Our data suggest that vitamin A deficiency affects the severity of ocular GVHD in adults.
异基因造血干细胞移植（HSCT）是治疗一系列遗传性和获得性血液系统疾病的成熟治疗选择。然而，移植物抗宿主病（GVHD）仍然是异基因HSCT受者非复发死亡率的主要原因。眼部受累在高达80%的慢性GVHD患者中出现。在我们的病例中，怀疑GVHD患者存在维生素A缺乏。进行血清维生素A检测以证实临床怀疑。我们的研究显示，慢性肝脏GVHD患者血清维生素A水平显著降低。尽管已经有许多研究评估GVHD患者的眼部表现，但据我们所知，本研究是首次在人类中研究维生素A与GVHD眼部表现之间的关系。我们的数据表明，维生素A缺乏会影响成人眼部GVHD的严重程度。
