Zheng Jianwei, Taylor Brian, Chen Xiao
Division of Hematology & Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
J Immunol Res Ther. 2018;3(1):124-128. Epub 2018 Jun 3.
Vitamin A is an essential micronutrient that participates in a wide range of biological processes. Retinoic acid (RA) is an active metabolite of vitamin A that functions as an immune regulator. Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). It is characterized by extensive inflammation arising from an alloimmune response involving various host and donor immune cells. Since vitamin A affects different immune cell lineages and regulates an array of immune responses, vitamin A, and more specifically retinoic acid, is likely to influence the incidence and/or severity of GVHD. Indeed, recent preclinical and clinical data support this concept. In this review, we briefly summarize recent advances in our understanding of the potential role of vitamin A in modulating GVHD risk after allogeneic HSCT.
维生素A是一种必需的微量营养素，参与广泛的生物学过程。视黄酸（RA）是维生素A的一种活性代谢产物，具有免疫调节功能。移植物抗宿主病（GVHD）是异基因造血干细胞移植（HSCT）的主要并发症。其特征是由涉及各种宿主和供体免疫细胞的同种异体免疫反应引起的广泛炎症。由于维生素A影响不同的免疫细胞谱系并调节一系列免疫反应，维生素A，更具体地说是视黄酸，可能会影响GVHD的发生率和/或严重程度。事实上，最近的临床前和临床数据支持这一概念。在本综述中，我们简要总结了我们对维生素A在调节异基因HSCT后GVHD风险中的潜在作用的最新认识进展。
