1 Massachusetts General Hospital, USA.
2 Harvard Medical School, USA.
Autism. 2018 Oct;22(7):804-813. doi: 10.1177/1362361317704420. Epub 2017 Jul 9.
We examine whether behavioral, mental health, and physical health characteristics of children with autism are associated with baseline and change in health-related quality of life. We measured health-related quality of life with the Pediatric Quality of Life Inventory 4.0 total scores from children enrolled in the Autism Treatment Network. We used linear mixed model regressions with random slopes. Predictors of lower health-related quality of life at baseline included demographic and insurance characteristics, diagnosis, higher Child Behavior Checklist internalizing and externalizing scores, sleep problems by Children's Sleep Habits Questionnaire, seizures, gastrointestinal problems, and mental health problems. Several characteristics had different associations over time. This study demonstrates that in addition to behavioral and autism-related characteristics, physical and mental health conditions are associated with health-related quality of life in children with autism.
我们研究了自闭症儿童的行为、心理健康和身体健康特征是否与健康相关生活质量的基线和变化相关。我们使用自闭症治疗网络中入组儿童的儿童生活质量量表 4.0 总评分来衡量健康相关生活质量。我们使用具有随机斜率的线性混合模型回归。基线时健康相关生活质量较低的预测因素包括人口统计学和保险特征、诊断、儿童行为检查表内化和外化评分较高、儿童睡眠习惯问卷的睡眠问题、癫痫发作、胃肠道问题和心理健康问题。几个特征随时间有不同的关联。本研究表明，除了行为和自闭症相关特征外，身体和心理健康状况也与自闭症儿童的健康相关生活质量相关。
