双侧原发性卵巢非霍奇金淋巴瘤与生育力保留：5年随访
Bilateral primary ovarian non-Hodgkin's lymphoma and fertility preservation: 5-year follow-up.
作者信息
Grigoriadis C, Tympa A, Chasiakou A, Baka S, Botsis D, Hassiakos D
出版信息
G Chir. 2017 Mar-Apr;38(2):77-79. doi: 10.11138/gchir/2017.38.2.077.
AIM
Primary ovarian non-Hodgkin's lymphoma is a very rare disease. Median age at diagnosis is estimated at 42 years, something that leads to fertility preservation issues in many cases. This was a case report study, presenting a rare case of bilateral primary ovarian non-Hodgkin's lymphoma.
CASE REPORT
A 38-year old nulliparous woman, underwent exploratory laparotomy because of bilateral ovarian masses. Left salpingooophorectomy, partial omentectomy and excision of an ovarian mass of the right ovary was performed. Great effort in order to preserve healthy ovarian tissue of the right ovary as well as the right fallopian tube was given, due to fertility reasons. Final histology showed bilateral diffuse large B-cell primary ovarian non-Hodgkin's lymphoma. Postoperatively, the patient underwent chemotherapy with the CHOP regimen in combination with rituximab. Five years after initial diagnosis, the patient remains well with normal menstrual cycle, without evidence of recurrence.
DISCUSSION
Fertility preservation issues in some cases of rare gynecological malignancies could be managed via minimally invasive oncological approach.
目的
原发性卵巢非霍奇金淋巴瘤是一种非常罕见的疾病。诊断时的中位年龄估计为42岁，这在许多情况下会导致生育力保留问题。这是一项病例报告研究，呈现了一例罕见的双侧原发性卵巢非霍奇金淋巴瘤病例。
病例报告
一名38岁未生育的女性因双侧卵巢肿块接受了剖腹探查术。进行了左侧输卵管卵巢切除术、部分大网膜切除术以及右侧卵巢肿块切除术。出于生育原因，尽力保留右侧卵巢以及右侧输卵管的健康卵巢组织。最终组织学检查显示为双侧弥漫性大B细胞原发性卵巢非霍奇金淋巴瘤。术后，患者接受了CHOP方案联合利妥昔单抗的化疗。初次诊断五年后，患者情况良好，月经周期正常，无复发迹象。
讨论
某些罕见妇科恶性肿瘤病例中的生育力保留问题可通过微创肿瘤学方法处理。
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