Costa José J N, Souza Glaucinete B, Soares Maria A A, Ribeiro Regislane P, van den Hurk Robert, Silva José R V
Biotechnology Nucleus of Sobral - NUBIS, Federal University of Ceara, Sobral, CE, Brazil.
Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Histol Histopathol. 2018 Feb;33(2):121-132. doi: 10.14670/HH-11-917. Epub 2017 Jul 10.
Infertility is the result of failure due to an organic disorder of the reproductive organs, especially their gametes. Recently, much progress has been made on generating germ cells, including oocytes, from various types of stem cells. This review focuses on advances in female germ cell differentiation from different kinds of stem cells, with emphasis on embryonic stem cells, adult stem cells, and induced pluripotent stem cells. The advantages and disadvantages of the derivation of female germ cells from several types of stem cells are also highlighted, as well as the ability of stem cells to generate mature and functional female gametes. This review shows that stem cell therapies have opened new frontiers in medicine, especially in the reproductive area, with the possibility of regenerating fertility.
不孕症是生殖器官尤其是其配子的器质性疾病导致的功能衰竭结果。近来，在从各种类型干细胞生成生殖细胞（包括卵母细胞）方面已取得很大进展。本综述聚焦于不同种类干细胞向雌性生殖细胞分化的进展，重点关注胚胎干细胞、成体干细胞和诱导多能干细胞。还强调了从几种类型干细胞衍生雌性生殖细胞的优缺点，以及干细胞生成成熟且有功能的雌性配子的能力。本综述表明，干细胞疗法已在医学领域开辟了新前沿，尤其是在生殖领域，具有恢复生育能力的可能性。
