哺乳动物的性腺早期发育和性别决定。
Early Gonadal Development and Sex Determination in Mammal.
机构信息
National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510630, China.
Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, South China Agricultural University, Guangzhou 510630, China.
出版信息
Int J Mol Sci. 2022 Jul 6;23(14):7500. doi: 10.3390/ijms23147500.
Sex determination is crucial for the transmission of genetic information through generations. In mammal, this process is primarily regulated by an antagonistic network of sex-related genes beginning in embryonic development and continuing throughout life. Nonetheless, abnormal expression of these sex-related genes will lead to reproductive organ and germline abnormalities, resulting in disorders of sex development (DSD) and infertility. On the other hand, it is possible to predetermine the sex of animal offspring by artificially regulating sex-related gene expression, a recent research hotspot. In this paper, we reviewed recent research that has improved our understanding of the mechanisms underlying the development of the gonad and primordial germ cells (PGCs), progenitors of the germline, to provide new directions for the treatment of DSD and infertility, both of which involve manipulating the sex ratio of livestock offspring.
性别决定对于遗传信息在世代间的传递至关重要。在哺乳动物中，这个过程主要由性相关基因的拮抗网络调控，从胚胎发育开始，并持续贯穿整个生命周期。然而，这些性相关基因的异常表达会导致生殖器官和生殖细胞的异常，从而导致性别发育障碍（DSD）和不孕不育。另一方面，通过人工调节性相关基因的表达来预先确定动物后代的性别，是最近的一个研究热点。本文综述了近年来在性腺和原始生殖细胞（PGCs）发育机制方面的研究进展，为 DSD 和不孕不育的治疗提供了新的方向，这两者都涉及到操纵家畜后代的性别比例。
Zotero 插件