Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center (Dr Chao, Ms Raymond, Ms Leo, Dr Abadjian); Department of Radiology and Biomedical Imaging (Dr Chao); and Department of Psychiatry (Dr Chao), University of California, San Francisco, San Francisco, California.
J Occup Environ Med. 2017 Oct;59(10):923-929. doi: 10.1097/JOM.0000000000001082.
To replicate and expand our previous findings of smaller hippocampal volumes in Gulf War (GW) veterans with predicted exposure to the Khamisiyah plume.
Total hippocampal and hippocampal subfield volumes were quantified from 3 Tesla magnetic resonance images in 113 GW veterans, 62 of whom had predicted exposure as per the Department of Defense exposure models.
Veterans with predicted exposure had smaller total hippocampal and CA3/dentate gyrus volumes compared with unexposed veterans, even after accounting for potentially confounding genetic and clinical variables. Among veterans with predicted exposure, memory performance was positively correlated with hippocampal volume and negatively correlated with estimated exposure levels and self-reported memory difficulties.
These results replicate and extend our previous finding that low-level exposure to chemical nerve agents from the Khamisiyah pit demolition has detrimental, lasting effects on brain structure and function.
复制并扩展我们之前的研究结果，即在海湾战争（GW）老兵中，那些预计接触过哈米斯米亚烟云的人的海马体体积更小。
从 113 名海湾战争老兵的 3 特斯拉磁共振图像中定量测量总海马体和海马体亚区体积，其中 62 名老兵的预计接触量符合国防部的暴露模型。
与未暴露的老兵相比，预计接触过的老兵的总海马体和 CA3/齿状回体积更小，即使考虑到潜在的混杂遗传和临床变量也是如此。在有预测暴露的老兵中，记忆表现与海马体体积呈正相关，与估计的暴露水平和自我报告的记忆困难呈负相关。
这些结果复制并扩展了我们之前的发现，即从哈米斯米亚弹坑拆除中低水平接触化学神经毒剂对大脑结构和功能有不利的、持久的影响。
