Bullman Tim A, Mahan Clare M, Kang Han K, Page William F
Department of Veterans Affairs, Veterans Health Administration, Mail Stop 135, Environmental Epidemiology Service, 810 Vermont Ave, Washington, DC 20420, USA.
Am J Public Health. 2005 Aug;95(8):1382-8. doi: 10.2105/AJPH.2004.045799.
We investigated whether US Army Gulf War veterans who were potentially exposed to nerve agents during the March 1991 weapons demolitions at Khamisiyah, Iraq, are at increased risk of cause-specific mortality.
The cause-specific mortality of 100487 exposed US Army Gulf War veterans was compared with that of 224980 unexposed US Army Gulf War veterans. Exposure was determined with the Department of Defense 2000 plume model. Relative risk estimates were derived from Cox proportional hazards models.
The risks of most disease-related mortality were similar for exposed and unexposed veterans. However, exposed veterans had an increased risk of brain cancer deaths (relative risk [RR]=1.94; 95% confidence interval [CI]=1.12, 3.34). The risk of brain cancer death was larger among those exposed 2 or more days than those exposed 1 day when both were compared separately to all unexposed veterans (RR=3.26; 95% CI=1.33, 7.96; RR=1.72; 95% CI=0.95,3.10, respectively).
Exposure to chemical munitions at Khamisiyah may be associated with an increased risk of brain cancer death. Additional research is required to confirm this finding.
我们调查了在1991年3月伊拉克哈米西耶武器销毁期间可能接触神经毒剂的美国陆军海湾战争退伍军人,其特定病因死亡率是否增加。
将100487名接触过的美国陆军海湾战争退伍军人的特定病因死亡率与224980名未接触过的美国陆军海湾战争退伍军人的死亡率进行比较。接触情况通过国防部2000年羽流模型确定。相对风险估计值来自Cox比例风险模型。
接触过和未接触过的退伍军人中,大多数与疾病相关的死亡风险相似。然而,接触过的退伍军人患脑癌死亡的风险增加(相对风险[RR]=1.94;95%置信区间[CI]=1.12,3.34)。当分别将接触2天或更长时间的退伍军人和接触1天的退伍军人与所有未接触过的退伍军人进行比较时,前者患脑癌死亡的风险更大(RR分别为3.26;95%CI=1.33,7.96;RR=1.72;95%CI=0.95,3.10)。
在哈米西耶接触化学弹药可能与脑癌死亡风险增加有关。需要进一步研究来证实这一发现。