退伍军人事务部海湾战争退伍军人疾病生物样本库：支持对海湾战争退伍军人疾病的研究。

The Department of Veterans Affairs Gulf War Veterans' Illnesses Biorepository: Supporting Research on Gulf War Veterans' Illnesses.

作者信息

Brady Christopher B, Robey Ian, Stein Thor D, Huber Bertrand R, Riley Jessica, Abdul Rauf Nazifa, Spencer Keith R, Walt Gabriel, Adams Latease, Averill James G, Walker Sean, McKee Ann C, Thomson Stephen P, Kowall Neil W

机构信息

Research and Development Service, VA Boston Healthcare System, Boston, MA 02130, USA.

Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.

出版信息

Brain Sci. 2021 Oct 14;11(10):1349. doi: 10.3390/brainsci11101349.

DOI:10.3390/brainsci11101349

PMID:34679413

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8533803/

Abstract

AIMS

To introduce a resource supporting research on Gulf War illness (GWI) and related disorders, the Gulf War Veterans' Illnesses Biorepository (GWVIB).

METHODS

Gulf War era veterans (GWVs) are recruited nationally and enrolled via telephone and email/postal mail. Enrolled veterans receive annual telephone and mail follow-up to collect health data until their passing. A postmortem neuropathological examination is performed, and fixed and frozen brain and spinal cord samples are banked to support research. Investigators studying GWI and related disorders may request tissue and data from the GWVIB.

RESULTS

As of September 2021, 127 GWVs from 39 states were enrolled; 60 met the criteria for GWI, and 14 met the criteria for chronic multisymptom illness (CMI). Enrollees have been followed up to six years. Postmortem tissue recoveries were performed on 14 GWVs. The most commonly found neuropathologies included amyotrophic lateral sclerosis, chronic traumatic encephalopathy, and Lewy body disease. Tissue was of good quality with an average RNA integrity number of 5.8 (SD = 1.0) and ≥4.8 in all of the cases.

DISCUSSION

The availability of health data and high-quality CNS tissue from this well-characterized GWV cohort will support research on GWI and related disorders affecting GWVs. Enrollment is ongoing.

摘要

目的

介绍一个支持海湾战争综合症（GWI）及相关疾病研究的资源，即海湾战争退伍军人疾病生物样本库（GWVIB）。

方法

在全国范围内招募海湾战争时期的退伍军人（GWVs），通过电话和电子邮件/邮政信件进行登记。登记的退伍军人每年接受电话和信件随访，以收集健康数据，直至去世。进行尸检神经病理学检查，并将固定和冷冻的脑和脊髓样本储存起来以支持研究。研究GWI及相关疾病的研究人员可以从GWVIB请求获取组织和数据。

结果

截至2021年9月，来自39个州的127名GWVs已登记；60人符合GWI标准，14人符合慢性多症状疾病（CMI）标准。登记人员已接受长达六年的随访。对14名GWVs进行了尸检组织回收。最常见的神经病理学包括肌萎缩侧索硬化症、慢性创伤性脑病和路易体病。组织质量良好，所有病例的平均RNA完整性数值为5.8（标准差=1.0）且≥4.8。