Stephens Jaclyn A, Salorio Cynthia F, Barber Anita D, Risen Sarah R, Mostofsky Stewart H, Suskauer Stacy J
a Kennedy Krieger Institute , Johns Hopkins School of Medicine , Baltimore , MD , USA.
b Department of Physical Medicine and Rehabilitation , Johns Hopkins School of Medicine , Baltimore , MD , USA.
Dev Neurorehabil. 2018 Oct;21(7):423-430. doi: 10.1080/17518423.2017.1338777. Epub 2017 Jul 10.
This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI).
Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks.
Collectively, these preliminary findings suggest that functional connectivity between DMN and BA 40 may relate to longterm functional outcomes in chronic pediatric TBI.
本研究检测了默认模式网络（DMN）的功能连接性，并在一组患有慢性轻度至中度创伤性脑损伤（TBI）的儿童试点队列中研究了脑-行为关系。
与未受伤的同龄人相比，患有TBI的儿童在DMN与右侧布罗德曼40区（BA 40）之间表现出较少的反相关功能连接。在患有TBI的儿童中，DMN与右侧BA 40之间更多的异常（较少反相关）连接与反应抑制任务的较差表现相关。
总体而言，这些初步发现表明，DMN与BA 40之间的功能连接可能与慢性小儿TBI的长期功能结果有关。
