Zhang Er-Lei, Gu Jin, Zhang Zun-Yi, Dong Ke-Shuai, Liang Bin-Yong, Huang Zhi-Yong
Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Oncol Lett. 2017 Jul;14(1):971-976. doi: 10.3892/ol.2017.6178. Epub 2017 May 16.
Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression profiles of 3 patients with HCC with familial aggregation of HCC and HBV infection and 1 healthy volunteer were examined by microarray analysis, in order to identify relevant miRNAs involved in the pathogenesis of HCC with familial aggregation and HBV infection. The results indicated that 26 miRNAs exhibited a ≥20-fold increase or decrease in the plasma of patients with HCC, compared with the healthy control (24 upregulated and 2 downregulated). Among these altered miRNAs, 15 of them have been reported in HCC. The other 11 miRNAs have never been reported in HCC. These differentially-expressed miRNAs may be potential molecular markers for HCC pathogenesis and development.
众多研究表明，微小RNA（miRNA）对肝癌发生有显著影响。然而，家族聚集性和乙型肝炎病毒（HBV）感染的肝细胞癌（HCC）患者的miRNA表达谱尚未阐明。在本研究中，通过微阵列分析检测了3例具有HCC家族聚集性且感染HBV的HCC患者和1名健康志愿者的血浆miRNA表达谱，以鉴定参与HCC家族聚集性和HBV感染发病机制的相关miRNA。结果表明，与健康对照相比，26种miRNA在HCC患者血浆中表现出≥20倍的增加或减少（24种上调，2种下调）。在这些改变的miRNA中，有15种已在HCC中报道。另外11种miRNA从未在HCC中报道过。这些差异表达的miRNA可能是HCC发病机制和发展的潜在分子标志物。
