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细胞膜钠转运:人体阻力血管与白细胞之间的相关性

Cell membrane sodium transport: a correlation between human resistance vessels and leucocytes.

作者信息

Aalkjaer C, Heagerty A M, Parvin S D, Bell P R, Bing R F, Swales J D

出版信息

Lancet. 1986 Mar 22;1(8482):649-51. doi: 10.1016/s0140-6736(86)91726-5.

DOI:10.1016/s0140-6736(86)91726-5
PMID:2869349
Abstract

Sodium efflux was studied in leucocytes and resistance vessels from omental fat from 18 subjects undergoing laparotomy. The efflux of sodium was considerably faster from resistance vessels than from leucocytes, but there was a significant correlation between total efflux rate constants in the two tissues. This was attributable to a highly significant correlation between active sodium pumping as assessed by the ouabain-sensitive sodium efflux rate constants observed in both tissues. These results indicate that intrinsic characteristics of cell membrane electrolyte transport are shared by the leucocyte and vascular smooth muscle in human beings. Therefore, leucocytes can be used to provide information about altered vascular ion handling.

摘要

对18名接受剖腹手术患者网膜脂肪中的白细胞和阻力血管的钠流出情况进行了研究。钠从阻力血管中的流出速度明显快于白细胞,但两种组织中的总流出速率常数之间存在显著相关性。这归因于两种组织中观察到的哇巴因敏感钠流出速率常数所评估的主动钠泵之间高度显著的相关性。这些结果表明,人类白细胞和血管平滑肌具有共同的细胞膜电解质转运内在特性。因此,白细胞可用于提供有关血管离子处理改变的信息。

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1
Cell membrane sodium transport: a correlation between human resistance vessels and leucocytes.细胞膜钠转运:人体阻力血管与白细胞之间的相关性
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2
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引用本文的文献

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Alterations in sodium metabolism as an etiological model for hypertension.作为高血压病因模型的钠代谢改变。
Cardiovasc Drugs Ther. 1995 Jun;9(3):377-99. doi: 10.1007/BF00879027.
2
Leucocyte sodium efflux and electrolyte content in insulin treated diabetes.胰岛素治疗糖尿病时的白细胞钠外流及电解质含量
Diabetologia. 1988 Nov;31(11):821-4. doi: 10.1007/BF00277484.
3
Glimpses of the mechanisms of hypertension.高血压机制一瞥。
Br Med J (Clin Res Ed). 1986 Oct 11;293(6552):901-2. doi: 10.1136/bmj.293.6552.901.
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Blood pressure: from cells to populations. The Bradshaw lecture 1987.血压:从细胞到人群。1987年布拉德肖讲座
J R Coll Physicians Lond. 1988 Jan;22(1):11-5.
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Increase in plasma potassium concentration following indomethacin administration: absence of a role for membrane Na-K ATPase.吲哚美辛给药后血浆钾浓度升高:膜钠钾ATP酶未发挥作用
Agents Actions. 1987 Oct;22(1-2):131-3. doi: 10.1007/BF01968828.
6
[Intracellular free calcium and plasma calcium in patients with essential hypertension. Is there a correlation between extracellular and intracellular disorders of calcium regulation in essential hypertension?].
Klin Wochenschr. 1988 May 16;66(10):455-61. doi: 10.1007/BF01745518.
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Leucocyte sodium pump activity after meals or insulin in normal and obese subjects: cause for increased energetic efficiency in obesity?正常人和肥胖者进食或注射胰岛素后的白细胞钠泵活性:肥胖者能量效率提高的原因?
Br Med J (Clin Res Ed). 1987 Nov 28;295(6610):1369-73. doi: 10.1136/bmj.295.6610.1369.
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Arch Dis Child. 1990 Oct;65(10):1154-7. doi: 10.1136/adc.65.10.1154.
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