Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Sci Prog. 2017 Mar 1;100(1):25-44. doi: 10.3184/003685017X14858694684395.
The developments in crystallography, since it was first covered in Science Progress in 1917, following the formulation of the Bragg equation, are described. The advances in instrumentation and data analysis, coupled with the application of computational methods to data analysis, have enabled the solution of molecular structures from the simplest binary systems to the most complex of biological structures. These developments are shown to have had major impacts in the development of chemical bonding theory and in offering an increasing understanding of enzyme-substrate interactions. The advent of synchrotron radiation sources has opened a new chapter in this multi-disciplinary field of science.
自 1917 年布拉格方程提出后，晶体学首次在《科学进展》中得到报道，自此之后，晶体学取得了一系列发展。仪器设备和数据分析方法的进步，加上计算方法在数据分析中的应用，使得从最简单的二元体系到最复杂的生物结构的分子结构的解析成为可能。这些发展对化学键理论的发展产生了重大影响，并使人们对酶-底物相互作用有了更深入的了解。同步辐射光源的出现为这一多学科科学领域开辟了新篇章。
