饮食来源的微小RNA：独角兽还是万灵药？
Diet-derived microRNAs: unicorn or silver bullet?
作者信息
Witwer Kenneth W, Zhang Chen-Yu
机构信息
Departments of Molecular and Comparative Pathobiology and Neurology, Johns Hopkins University, Baltimore, USA.
School of Life Sciences, Nanjing University, Nanjing, People's Republic of China.
出版信息
Genes Nutr. 2017 Jun 22;12:15. doi: 10.1186/s12263-017-0564-4. eCollection 2017.
In ancient lore, a bullet cast from silver is the only effective weapon against monsters. The uptake of active diet-derived microRNAs (miRNAs) in consumers may be the silver bullet long sought after in nutrition and oral therapeutics. However, the majority of scientists consider the transfer and regulation of consumer's gene activity by these diet-derived miRNAs to be a fantasy akin to spotting a unicorn. Nevertheless, groups like Dr. Chen-Yu Zhang's lab in Nanjing University have stockpiled breathtaking amounts of data to shoot down these naysayers. Meanwhile, Dr. Ken Witwer at John Hopkins has steadfastly cautioned the field to beware of fallacies caused by contamination, technical artifacts, and confirmation bias. Here, Dr. Witwer and Dr. Zhang share their realities of dietary miRNAs by answering five questions related to this controversial field.
在古代传说中，用银铸造的子弹是对抗怪物的唯一有效武器。消费者摄取源自日常饮食的活性微小RNA（miRNA）可能是营养与口腔治疗领域长期以来所追寻的“银弹”。然而，大多数科学家认为这些源自饮食的miRNA对消费者基因活性的转移和调控是一种幻想，类似于发现独角兽。尽管如此，像南京大学的陈宇教授实验室这样的团队已经积累了大量惊人的数据来反驳这些唱反调的人。与此同时，约翰·霍普金斯大学的肯·威特沃博士一直告诫该领域要警惕由污染、技术假象和确认偏误所导致的谬误。在此，威特沃博士和陈教授通过回答与这个有争议领域相关的五个问题，分享了他们对于饮食miRNA的看法。
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