Department of Immunology, Jagiellonian University Medical College, 18 Czysta St., 31-121 Krakow, Poland.
Int J Mol Sci. 2022 Jul 7;23(14):7554. doi: 10.3390/ijms23147554.
Considered an artifact just after discovery, the possibility of oral delivery of extracellular vesicles (EVs) and their functional cargos has recently gained much research attention. EVs from various sources, including edible plants, milk, bacteria and mammalian cells, have emerged as a platform for miRNA and drug delivery that seem to induce the expected immune effects locally and in distant tissues after oral administration. Such a possibility greatly expands the clinical applicability of EVs. The present review summarizes research findings that either support or deny the biological/therapeutical activity of orally administered EVs and their role in cross-species and cross-kingdom signaling.
在刚刚被发现时，被认为是一种人工制品，细胞外囊泡 (EVs) 的口服递送及其功能 cargo 的可能性最近引起了广泛的研究关注。来自各种来源的 EVs，包括食用植物、牛奶、细菌和哺乳动物细胞，已经成为 miRNA 和药物递送的平台，似乎在口服给药后能在局部和远处组织中诱导预期的免疫效应。这种可能性极大地扩展了 EVs 的临床应用。本综述总结了支持或否定口服给予的 EVs 的生物学/治疗活性及其在种间和跨领域信号传递中的作用的研究结果。
