Gundle Kenneth R, Bhatt Etasha M, Punt Stephanie E, Bompadre Viviana, Conrad Ernest U
Oregon Health & Science University, Department of Orthopaedics & Rehabilitation, Portland, USA.
Portland VA Medical Center, Operative Care Division, Portland, USA.
Open Orthop J. 2017 May 31;11:486-492. doi: 10.2174/1874325001711010486. eCollection 2017.
Many treatment options exist for unicameral bone cysts (UBC), without clear evidence of superiority. Meta-analyses have been limited by small numbers of patients in specific anatomic and treatment subgroups. The purpose of this study was to report the outcomes of injecting bone marrow aspirate and demineralized bone matrix (BMA/DBM) for the treatment of proximal humerus UBC.
Fifty-one patients with proximal humerus lesions treated by BMA/DBM injection were retrospectively reviewed from a single academic medical center.
The mean number of injections performed per patient was 2.14 (range 1-5). Eleven patients underwent only one injection (22%), an additional 19 patients completed treatment after two injections (37%), four patients healed after three injections (8%), and one patient healed after four injections (2%). The cumulative success rate of serial BMA/DBM injections was 22% (11/51), 58% (30/51), 67% (34/51), and 69% (35/51). Eleven patients (22%) ultimately underwent open curettage and bone grafting, and five patients (10%) were treated with injection of calcium phosphate bone substitute.
A BMA/DBM injection strategy avoided an open procedure in 78% of patients with a proximal humerus UBC. The majority of patients underwent at least 2 injection treatments.
Level IV retrospective cohort study.
对于单纯性骨囊肿（UBC）存在多种治疗选择，但尚无明确的优越性证据。荟萃分析受到特定解剖和治疗亚组中患者数量较少的限制。本研究的目的是报告注射骨髓抽吸物和脱矿骨基质（BMA/DBM）治疗肱骨近端UBC的结果。
从一个学术医学中心回顾性分析了51例接受BMA/DBM注射治疗的肱骨近端病变患者。
每位患者平均注射次数为2.14次（范围1 - 5次）。11例患者仅接受了一次注射（22%），另外19例患者在两次注射后完成治疗（37%），4例患者在三次注射后治愈（8%），1例患者在四次注射后治愈（2%）。连续BMA/DBM注射的累积成功率分别为22%（11/51）、58%（30/51）、67%（34/51）和69%（35/51）。11例患者（22%）最终接受了切开刮除植骨术，5例患者（10%）接受了磷酸钙骨替代物注射治疗。
BMA/DBM注射策略使78%的肱骨近端UBC患者避免了开放性手术。大多数患者接受了至少2次注射治疗。
IV级回顾性队列研究。
