Huang Qian, Zhou Ying, Liu Lin-Yun
Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200032, China.
Exp Brain Res. 2017 Sep;235(9):2893-2899. doi: 10.1007/s00221-017-5021-5. Epub 2017 Jul 10.
Effects of post-weaning isolation on depressive- and anxiety-like behaviors in rodents have been well studied in the past. However, few studies included both sexes in a single experiment to study the sex difference in this animal model. The present study investigated the effect of post-weaning isolation on anxiety- and depressive-like behaviors in both male and female C57BL/6 J mice. Mice were individually or grouped housed from postnatal day 21 for 5 weeks until behavioral tests began. The results showed that social isolation resulted in increased anxiety in the open field. Isolated-reared female, but not male mice showed an increased transition between two compartments in the light-dark box and a decreased immobile time in the forced swim test. We conclude that post-weaning isolation has a sex-specific effect on emotional behaviors.
断奶后隔离对啮齿动物抑郁样和焦虑样行为的影响在过去已得到充分研究。然而，很少有研究在单一实验中纳入雌雄两性来研究这种动物模型中的性别差异。本研究调查了断奶后隔离对雄性和雌性C57BL/6 J小鼠焦虑样和抑郁样行为的影响。从出生后第21天开始，将小鼠单独或分组饲养5周，直至开始行为测试。结果表明，社会隔离导致旷场试验中的焦虑增加。隔离饲养的雌性而非雄性小鼠在明暗箱中两个隔间之间的转换增加，在强迫游泳试验中的不动时间减少。我们得出结论，断奶后隔离对情绪行为有性别特异性影响。
