Eid Aya H, S Zaki Eman, Sabry Miral O, El-Shiekh Riham A, Khalaf Samar S
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Faculty of Science, National University of Singapore, Singapore, Singapore.
Inflammopharmacology. 2025 Mar 19. doi: 10.1007/s10787-025-01685-2.
Allergies are a common health issue affecting many people around the world, especially in developed countries. They occur when the immune system overreacts to substances that are usually harmless. Some common allergic conditions include asthma, sinus infections, skin rashes, food allergies, hay fever, severe allergic reactions, eczema, swelling, and reactions to medications or insect stings. The causes of these allergies are complex and often linked to genetics, which can lead to heightened immune responses known as atopy. Throughout history, plant extracts have been used for various purposes, including medicine and food. In addition, their bioactive compounds show a wide range of beneficial effects, such as reducing allergic reactions, fighting oxidative stress, mast cell stabilizers, and lowering inflammation, highlighting their potential for treating various health conditions. Flavonoids and phenolic compounds are commonly used in anaphylaxis for their potent anti-inflammatory action. This review aims to promote the use of natural products as potential treatments for anaphylaxis. In addition, the discovery of new drugs derived from natural sources holds significant promise for the management of anaphylaxis.
过敏是一个常见的健康问题，影响着全球许多人，尤其是在发达国家。当免疫系统对通常无害的物质产生过度反应时，就会发生过敏。一些常见的过敏病症包括哮喘、鼻窦感染、皮疹、食物过敏、花粉热、严重过敏反应、湿疹、肿胀以及对药物或昆虫叮咬的反应。这些过敏的原因很复杂，通常与遗传有关，这可能导致称为特应性的免疫反应增强。纵观历史，植物提取物已被用于各种目的，包括医药和食品。此外，它们的生物活性化合物显示出广泛的有益作用，如减少过敏反应、对抗氧化应激、作为肥大细胞稳定剂以及减轻炎症，突出了它们治疗各种健康状况的潜力。黄酮类化合物和酚类化合物因其强大的抗炎作用而常用于过敏反应。本综述旨在促进将天然产物用作过敏反应的潜在治疗方法。此外，从天然来源发现新药对过敏反应的管理具有重大前景。
