通过负离子 Claisen 重排和环化复分解反应合成布里亚烷二萜。
Approach to the Synthesis of Briarane Diterpenes through a Dianionic Claisen Rearrangement and Ring-Closing Metathesis.
机构信息
Kenan, Caudill, Venable, and Murray Laboratories of Chemistry University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
出版信息
Org Lett. 2017 Jul 21;19(14):3907-3910. doi: 10.1021/acs.orglett.7b01806. Epub 2017 Jul 11.
PMID:28696715
Abstract
The synthesis of the briarane-brianthein A core has been accomplished utilizing an extension of the dianionic Ireland-Claisen rearrangement to establish the C1 quaternary carbon and the adjacent C10 ring juncture stereocenters. Two sequential ring-closing metathesis reactions were exploited to construct the 6-10 trans fused ring system.
摘要
利用阴离子 Ireland-Claisen 重排的扩展，完成了石蒜烷-石蒜滨 A 核心的合成，从而建立了 C1 季碳原子和相邻的 C10 环接头立体中心。通过两个连续的环 closing metathesis 反应来构建 6-10 个反式稠合环系统。
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