Weistenhöfer Wobbeke, Uter Wolfgang, Drexler Hans
a Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine , Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Erlangen , Germany.
b Department of Medical Informatics , Biometry and Epidemiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU) , Erlangen , Germany.
J Toxicol Environ Health A. 2017;80(7-8):396-404. doi: 10.1080/10937404.2017.1304741. Epub 2017 Jul 11.
Wearing of occlusive gloves during the whole working shift is considered a risk factor for developing hand eczema, similar to wet work. Moreover, the increased hydration due to glove occlusion may lead to brittle nails. Two hundred and seventy clean room workers, wearing occlusive gloves for prolonged periods, and 135 administrative employees not using gloves were investigated. This included a dermatological examination of the nails and the hands, using the Hand Eczema ScoRe for Occupational Screening (HEROS), measurement of transepidermal water loss (TEWL), and a standardized interview. Of the clean room workers, 39%, mainly women, reported nail problems, mostly brittle nails with onychoschisis. Skin score values showed no significant differences between HEROS values of both groups. TEWL values of exposed subjects were similar to TEWL values of controls 40 min after taking off the occlusive gloves. In a multiple linear regression analysis, male gender and duration of employment in the clean room were associated with a significant increase in TEWL values. The effect of occlusion on TEWL seems to be predominantly transient and not be indicative of a damaged skin barrier. This study confirmed the results of a previous investigation showing no serious adverse effect of wearing of occlusive gloves on skin condition without exposure to additional hazardous substances. However, occlusion leads to softened nails prone to mechanical injury. Therefore, specific prevention instructions are required to pay attention to this side effect of occlusion.
在整个工作班次中佩戴封闭性手套被认为是引发手部湿疹的一个风险因素，类似于从事湿作业。此外，因手套封闭导致的皮肤水分增加可能会使指甲变脆。对270名长时间佩戴封闭性手套的洁净室工作人员以及135名不使用手套的行政人员进行了调查。这包括使用职业筛查手部湿疹评分（HEROS）对指甲和手部进行皮肤科检查、测量经表皮水分流失（TEWL）以及进行标准化访谈。在洁净室工作人员中，39%（主要是女性）报告有指甲问题，大多是伴有甲裂的脆甲。两组的HEROS值在皮肤评分上无显著差异。在摘掉封闭性手套40分钟后，接触组的TEWL值与对照组的TEWL值相似。在多元线性回归分析中，男性性别和在洁净室的工作时长与TEWL值的显著增加有关。封闭对TEWL的影响似乎主要是短暂的，并不表明皮肤屏障受损。本研究证实了先前一项调查的结果，即在不接触其他有害物质的情况下，佩戴封闭性手套对皮肤状况没有严重的不良影响。然而，封闭会导致指甲变软，容易受到机械损伤。因此，需要有具体的预防指导来关注封闭的这一副作用。
