Ramsing D W, Agner T
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
Contact Dermatitis. 1996 Apr;34(4):258-62. doi: 10.1111/j.1600-0536.1996.tb02196.x.
Gloves are indispensable in many occupations. Irritant skin reactions from gloves have, however, been reported. In the present study, the effect of long-term glove occlusion on normal skin (6 h/day for 14 days) was studied and, in addition, the effect of a cotton glove worn under the occlusive glove was also studied. 2 studies were performed (studies A and B). Study A: 19 volunteers wore an occlusive glove on normal skin 6 h/day for 14 days. They wore the glove on one hand only, while the other hand served as control. Study B: 18 volunteers wore occlusive gloves on both hands on normal skin. A cotton glove was worn under the occlusive glove on either the left or the right hand. Skin barrier function was evaluated by measurement of transepidermal water loss (TEWL) (Evaporimeter), skin hydration by electrical capacitance (Corneometer) and inflammation by erythema index (Derma-Spectrometer). The gloves used were hypoallergenic non-latex gloves. Results. Study A: glove occlusive on normal skin 6 h/day for 14 days had a significant negative effect on skin barrier function, as measured by TEWL. Study B: the negative effect on skin barrier function from occlusive gloves was prevented by the use of a cotton glove. It is concluded that gloves may be a substantial factor in the pathogenesis of cumulative irritant contact dermatitis, and that recommendations as to their use are important.
手套在许多职业中不可或缺。然而，已有手套引起刺激性皮肤反应的报道。在本研究中，研究了长期手套封闭对正常皮肤的影响（每天6小时，共14天），此外，还研究了在封闭性手套下佩戴棉手套的影响。进行了两项研究（研究A和研究B）。研究A：19名志愿者在正常皮肤上每天佩戴封闭性手套6小时，共14天。他们只在一只手上戴手套，另一只手作为对照。研究B：18名志愿者在正常皮肤上双手佩戴封闭性手套。在左手或右手上的封闭性手套下佩戴棉手套。通过测量经表皮水分流失（TEWL）（蒸发仪）评估皮肤屏障功能，通过电容测量（角质层水合测定仪）评估皮肤水合作用，通过红斑指数（皮肤光谱仪）评估炎症。所用手套为低过敏性非乳胶手套。结果。研究A：每天在正常皮肤上封闭手套6小时，共14天，对皮肤屏障功能有显著负面影响，通过TEWL测量。研究B：使用棉手套可防止封闭性手套对皮肤屏障功能的负面影响。得出结论，手套可能是累积性刺激性接触性皮炎发病机制中的一个重要因素，关于手套使用的建议很重要。
