Sue Laura Y, Batech Michael, Yadav Dhiraj, Pandol Stephen J, Blumentals William A, von Krusenstiern Lenore Soodak, Chen Wansu, Wu Bechien U
From the *Department of Internal Medicine, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA; †Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA; ‡Division of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA; §Center for Basic and Translational Pancreatic Research, Cedars-Sinai Medical Center, Los Angeles, CA; ∥Global HEOR and Epidemiology, Shire, Lexington, MA; ¶Clinical Research and Development, Shire, Lexington, MA; and #Center for Pancreatic Care, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.
Pancreas. 2017 Aug;46(7):874-879. doi: 10.1097/MPA.0000000000000860.
The aim of this study was to evaluate the effect of serum triglycerides on the development of multiple or persistent organ failure in patients with acute pancreatitis.
A retrospective cohort study was conducted among patients hospitalized for acute pancreatitis between 2006 and 2013. Triglyceride levels measured before and within 72 hours of admission were compared. In addition, the effect of triglyceride levels on the development of multiple or persistent organ failure during hospitalization for acute pancreatitis was assessed.
Among 2519 patients, 267 patients (10.6%) developed organ failure, of which 75 patients developed multiple system organ failure and 82 patients developed persistent organ failure. Triglyceride levels in patients who developed organ failure were initially much higher than in patients who did not develop organ failure, but by 72 hours into admission, approached levels of patients who did not develop organ failure. Approximately 8% of patients had triglyceride levels greater than 500 mg/dL, the majority of which had similarly high levels before admission.
Increased triglyceride levels were associated with the development of multiple or persistent organ failure among patients hospitalized with acute pancreatitis. Patients with high triglyceride levels at the time of admission were likely to have high triglyceride levels before admission.
本研究旨在评估血清甘油三酯对急性胰腺炎患者多器官功能障碍或持续性器官功能衰竭发生发展的影响。
对2006年至2013年期间因急性胰腺炎住院的患者进行回顾性队列研究。比较入院前及入院72小时内测得的甘油三酯水平。此外，评估甘油三酯水平对急性胰腺炎住院期间多器官功能障碍或持续性器官功能衰竭发生发展的影响。
在2519例患者中，267例（10.6%）发生器官功能衰竭，其中75例发生多系统器官功能衰竭，82例发生持续性器官功能衰竭。发生器官功能衰竭的患者的甘油三酯水平最初远高于未发生器官功能衰竭的患者，但入院72小时后，接近未发生器官功能衰竭患者的水平。约8%的患者甘油三酯水平高于500mg/dL，其中大多数患者入院前甘油三酯水平同样较高。
甘油三酯水平升高与急性胰腺炎住院患者多器官功能障碍或持续性器官功能衰竭的发生有关。入院时甘油三酯水平高的患者入院前甘油三酯水平可能也高。
