Steinbereithner K, Fitzal S, Schwarz S, Gilly H, Semsroth M, Weindlmayr-Goettel M
Cah Anesthesiol. 1984 Jan-Feb;32(1):5-10.
Pharmacodynamics of vecuronium have been studied in children 1 to 10 years old. Doses from 0.015 to 0.1 mg/kg were given and the effects measured mechanically and by electromyography. For 0.1 mg/kg the pharmacokinetics were established. A smaller distribution volume and higher plasma clearance in children as compared to adults have been found, while the dose-effect ratio is the same. The action of vecuronium is shorter in children than in adults.
已对1至10岁儿童的维库溴铵药效学进行了研究。给予0.015至0.1毫克/千克的剂量，并通过机械方法和肌电图测量效果。对于0.1毫克/千克的剂量，已确定了其药代动力学。与成人相比，儿童的分布容积较小，血浆清除率较高，而剂量效应比相同。维库溴铵在儿童中的作用比在成人中短。
