Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Department of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, Kishangarh, Ajmer 305801, India.
Drug Discov Today. 2018 Feb;23(2):300-314. doi: 10.1016/j.drudis.2017.06.009. Epub 2017 Jul 8.
Highly controllable dendritic structural design means dendrimers are a leading carrier in drug delivery applications. Dendrimer- and other nanocarrier-based hybrid systems are an emerging platform in the field of drug delivery. This review is a compilation of increasing reports of dendrimer interactions, such as dendrimer-liposome, dendrimer-carbon-nanotube, among others, known as hybrid carriers. This should prompt entirely new research with promising results for these hybrid carriers. It is assumed that such emerging hybrid nanosystems - from combining two already-established drug delivery platforms - could lead the way for the development of newer delivery systems with multiple applicability for latent theranostic applications in the future.
高度可控的树枝状结构设计意味着树枝状大分子是药物传递应用中的主要载体。树枝状大分子和其他基于纳米载体的混合系统是药物传递领域的一个新兴平台。本综述汇集了越来越多的关于树枝状大分子相互作用的报道，例如树枝状大分子-脂质体、树枝状大分子-碳纳米管等，这些都被称为混合载体。这应该会促使对这些混合载体进行全新的研究，并取得有前景的结果。可以假设，这种新兴的混合纳米系统——将两种已经确立的药物传递平台结合起来——可能为未来更具多种适用性的潜在治疗诊断应用的新型传递系统的发展开辟道路。
