Agren H, Lundqvist G
Psychoneuroendocrinology. 1984;9(3):233-48. doi: 10.1016/0306-4530(84)90003-9.
Somatostatin-like immunoreactivity was measured in the cerebrospinal fluid (CSF) of 85 inpatients with current or recent episodes of major depressive disorders, diagnosed according to Research Diagnostic Criteria (RDC) as assessed with the Schedule for Affective Disorders and Schizophrenia (SADS). Several biopsychiatric tests were run during the same week of investigation. Results indicate low levels of CSF somatostatin to be a state marker for episodes of depression characterized by sad appearance, feelings of tiredness, insomnia, and subjective inability to acknowledge any external precipitants for the depression. CSF somatostatin was negatively related to platelet monoamine oxidase (MAO) activity; MAO activity appeared to account better for the degree of melancholic features than did somatostatin. The ratio between 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) in CSF also correlated negatively with somatostatin. A positive relationship was noted between CSF xanthine and somatostatin. There was a highly significant curvilinear correlation between CSF somatostatin and serum TSH concentrations, but no correlations between CSF somatostatin and serum GH or prolactin, or with plasma cortisol before or after dexamethasone.
根据研究诊断标准（RDC），采用情感障碍和精神分裂症日程表（SADS）对85例患有当前或近期重度抑郁症发作的住院患者进行了脑脊液（CSF）中生长抑素样免疫反应性的测量。在调查的同一周内进行了多项生物精神病学测试。结果表明，脑脊液生长抑素水平低是抑郁症发作的一种状态标志物，其特征为面容悲伤、疲倦感、失眠以及主观上无法认识到抑郁症的任何外部诱发因素。脑脊液生长抑素与血小板单胺氧化酶（MAO）活性呈负相关；与生长抑素相比，MAO活性似乎能更好地解释抑郁特征的程度。脑脊液中3-甲氧基-4-羟基苯乙二醇（MHPG）与高香草酸（HVA）的比值也与生长抑素呈负相关。脑脊液黄嘌呤与生长抑素之间存在正相关关系。脑脊液生长抑素与血清促甲状腺激素（TSH）浓度之间存在高度显著的曲线相关性，但脑脊液生长抑素与血清生长激素（GH）或催乳素之间以及与地塞米松前后的血浆皮质醇之间均无相关性。
