Banki C M, Bissette G, Arato M, O'Connor L, Nemeroff C B
Am J Psychiatry. 1987 Jul;144(7):873-7. doi: 10.1176/ajp.144.7.873.
To further investigate the hypothesis that hyperactivity of the hypothalamic-pituitary-adrenal axis in patients with depression may be mediated by hypersecretion of corticotropin-releasing factor (CRF), the authors measured CRF-like immunoreactivity in CSF samples from 138 neurological control, 54 depressed, and 27 nondepressed (23 schizophrenic and four manic) subjects. The CSF CRF concentration was markedly higher (almost twofold) in depressed patients than in control subjects and nondepressed psychiatric patients. The concentration of CSF CRF was slightly but significantly higher in schizophrenic patients than in control subjects. These findings provide further support for the hypothesis that CRF hypersecretion occurs in major depression.
为了进一步研究抑郁症患者下丘脑 - 垂体 - 肾上腺轴功能亢进可能由促肾上腺皮质激素释放因子（CRF）分泌过多介导这一假说，作者测量了138名神经科对照者、54名抑郁症患者以及27名非抑郁症患者（23名精神分裂症患者和4名躁狂症患者）脑脊液样本中CRF样免疫反应性。抑郁症患者脑脊液中的CRF浓度显著高于（几乎是两倍）对照者和非抑郁症精神科患者。精神分裂症患者脑脊液中CRF的浓度比对照者略高，但有显著差异。这些发现为CRF分泌过多发生在重度抑郁症中的假说提供了进一步的支持。
