香肠树（非洲吊灯树）黄酮提取物对氯化铝诱导的实验性阿尔茨海默病具有神经保护作用。
Sausage tree (Kigelia africana) flavonoid extract is neuroprotective in AlCl-induced experimental Alzheimer's disease.
作者信息
Falode John Adeolu, Akinmoladun Afolabi C, Olaleye M Tolulope, Akindahunsi Afolabi A
机构信息
Department of Biochemistry, School of Sciences, The Federal University of Technology, P.M.B. 704, Akure, Nigeria; Department of Biochemistry, Faculty of Sciences, Federal University, Oye-Ekiti, Nigeria.
Department of Biochemistry, School of Sciences, The Federal University of Technology, P.M.B. 704, Akure, Nigeria.
出版信息
Pathophysiology. 2017 Dec;24(4):251-259. doi: 10.1016/j.pathophys.2017.06.001. Epub 2017 Jun 28.
Alzheimer's disease (AD) is a developmental neurodegenerative disorder for which there is no effective treatment or cure at present. In this study, the neuroprotective properties of a methanol extract of the leaves of Kigelia africana (KAE) and its flavonoid-rich fraction (FKAE) in aluminum chloride (AlCl)-induced experimental AD was evaluated. Symptoms mimicking AD were induced in male Sprague Dawley rats by administering 17mg/kg AlCl, orally, for six consecutive weeks. Pretreatment of animals with 50 and 100mg/kg KAE or FKAE for two weeks, followed by their co-administration with AlCl for a further four weeks ameliorated neurological deficits, cerebral oxidative stress, neurochemical disturbances and histoarchitectural alterations caused by AlCl intoxication. The results suggest that KAE and FKAE are promising therapeutic agents for AD.
阿尔茨海默病（AD）是一种目前尚无有效治疗或治愈方法的发育性神经退行性疾病。在本研究中，评估了非洲吊灯树树叶甲醇提取物（KAE）及其富含黄酮类成分（FKAE）在氯化铝（AlCl）诱导的实验性AD中的神经保护特性。通过连续六周口服给予17mg/kg AlCl，在雄性斯普拉格-道利大鼠中诱导出类似AD的症状。用50和100mg/kg KAE或FKAE对动物进行两周预处理，然后将它们与AlCl共同给药四周，改善了由AlCl中毒引起的神经功能缺损、脑氧化应激、神经化学紊乱和组织架构改变。结果表明，KAE和FKAE有望成为治疗AD的药物。
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