Bernocchi B, Carpentier R, Betbeder D
Inserm, LIRIC-UMR 995, F-59000 Lille, France; Université de Lille, LIRIC-UMR 995, F-59000 Lille, France; CHRU de Lille, LIRIC-UMR 995, F-59000 Lille, France.
Inserm, LIRIC-UMR 995, F-59000 Lille, France; Université de Lille, LIRIC-UMR 995, F-59000 Lille, France; CHRU de Lille, LIRIC-UMR 995, F-59000 Lille, France.
Int J Pharm. 2017 Sep 15;530(1-2):128-138. doi: 10.1016/j.ijpharm.2017.07.012. Epub 2017 Jul 8.
Nasal administration of vaccines is convenient for the potential stimulation of mucosal and systemic immune protection. Moreover the easy accessibility of the intranasal route renders it optimal for pandemic vaccination. Nanoparticles have been identified as ideal delivery systems and adjuvants for vaccine application. Heterogeneous protocols have been used for animal studies. This complicates the understanding of the formulation influence on the immune response and the comparison of the different nanoparticles approaches developed. Moreover anatomical and immunological differences between rodents and humans provide an additional hurdle in the rational development of nasal nanovaccines. This review will give a comprehensive expertise of the state of the art in nasal nanovaccines in animals and humans focusing on the nanomaterial used.
经鼻接种疫苗便于潜在地刺激黏膜和全身免疫保护。此外，鼻内给药途径易于操作，使其成为大流行疫苗接种的理想途径。纳米颗粒已被确定为疫苗应用的理想递送系统和佐剂。在动物研究中使用了不同的方案。这使得理解制剂对免疫反应的影响以及比较所开发的不同纳米颗粒方法变得复杂。此外，啮齿动物和人类之间的解剖学和免疫学差异为鼻内纳米疫苗的合理开发带来了额外障碍。本综述将全面介绍动物和人类鼻内纳米疫苗的最新技术水平，重点关注所使用的纳米材料。
