Department of Nuclear Medicine, Uniklinik RWTH Aachen University, Germany; Leibniz Institute for Interactive Materials - DWI, RWTH Aachen University, Germany.
Department of Nuclear Medicine, Uniklinik RWTH Aachen University, Germany; Institute of Inorganic Chemistry, RWTH Aachen University, Germany.
Methods. 2017 Nov 1;130:14-22. doi: 10.1016/j.ymeth.2017.07.004. Epub 2017 Jul 8.
In nuclear medicine, a theranostic probe describes a substance that combines diagnostic and therapeutic capabilities by radiolabeling it with different radionuclides. Next to a brief description of the different emitters (α, β, β, γ) used for imaging and/or therapy, the aim of this review is to summarize the most commonly used theranostic probes in nuclear medicine. Another goal is to give an idea which chemical requirements need to be fulfilled for radiolabeling with either therapeutic and/or diagnostic relevant nuclides. Furthermore, a perspective is given into the field of nanotheranostics which is gaining more and more attention in nuclear medicine. The combination has been called radionanomedicine and is a very proliferative field with an enormous potential.
在核医学中，治疗诊断探针是指通过用不同的放射性核素来标记该物质，从而将诊断和治疗功能结合在一起的一种物质。本文除了简要描述用于成像和/或治疗的不同发射体（α、β、β+、γ）外，还旨在总结核医学中最常用的治疗诊断探针。另一个目标是给出用治疗和/或诊断相关核素进行放射性标记所需满足的化学要求的想法。此外，本文还介绍了纳米治疗诊断学领域，该领域在核医学中越来越受到关注。这种结合被称为放射纳米医学，是一个具有巨大潜力的快速发展领域。
