Laschinsky Christina, Herrmann Ken, Fendler Wolfgang, Nader Michael, Lahner Harald, Hadaschik Boris, Sandach Patrick
Klinik für Nuklearmedizin, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.
Klinik für Endokrinologie, Diabetologie und Stoffwechsel, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland.
Radiologie (Heidelb). 2022 Oct;62(10):875-884. doi: 10.1007/s00117-022-01072-w.
The theranostic principle describes the diagnostic and therapeutic use of radioactive nuclides linked to biochemically active ligands. The oldest and most prominent field of application of theranostics in oncology is differentiated thyroid cancer treated by radioiodine therapy, which allows imaging of the iodine uptake and thus tumor manifestations by gamma (γ) radiation of radioiodine. Other areas of application include neuroendocrine tumors, castration-resistant prostate cancer and, in the context of individual therapeutic approaches, fibroblastic tumors. Imaging with beta-plus (β) emitters is mainly performed using so-called hybrid imaging: positron emission tomography (PET) in combination with computed tomography or magnetic resonance imaging (PET/CT or PET/MRI). Beta-minus (β) emitters are predominantly used in therapy, but the use of alpha (α) emitters is also increasing, thus, enabling targeted cancer treatment with mostly low-grade side effects.
治疗诊断学原理描述了与生物化学活性配体相连的放射性核素的诊断和治疗用途。治疗诊断学在肿瘤学中最古老且最突出的应用领域是通过放射性碘疗法治疗分化型甲状腺癌，该疗法可通过放射性碘的伽马（γ）辐射对碘摄取情况以及肿瘤表现进行成像。其他应用领域包括神经内分泌肿瘤、去势抵抗性前列腺癌，以及在个体化治疗方法背景下的纤维瘤。使用正电子（β⁺）发射体进行成像主要采用所谓的混合成像：正电子发射断层扫描（PET）与计算机断层扫描或磁共振成像相结合（PET/CT或PET/MRI）。负电子（β⁻）发射体主要用于治疗，但α发射体的使用也在增加，从而能够实现副作用大多较小的靶向癌症治疗。
