衰老的系统建模：从单个衰老细胞到简单的多细胞模型。
Systems modelling ageing: from single senescent cells to simple multi-cellular models.
作者信息
Martinez Guimera Alvaro, Welsh Ciaran, Dalle Pezze Piero, Fullard Nicola, Nelson Glyn, Roger Mathilde F, Przyborski Stefan A, Shanley Daryl P
机构信息
Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K.
The Babraham Institute, Babraham Campus, Cambridge, U.K.
出版信息
Essays Biochem. 2017 Jul 11;61(3):369-377. doi: 10.1042/EBC20160087. Print 2017 Jul 15.
Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.
系统建模已成功用于研究衰老的几个关键分子机制。现在，允许整合模型和方法以增强对模型信心的建模框架已经确立。在本文中，我们将讨论这些问题，并详细说明构建细胞衰老的整合模型的过程，该模型既适用于单个细胞，也适用于简单的组织环境。
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