Ashrafi Mahmoud Reza, Tavasoli Ali Reza, Alizadeh Houman, Zare Noghabi Javad, Parvaneh Nima
Department of Pediatrics, Division of Pediatric Neurology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Pediatrics, Division of Pediatric Radiology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Child Neurol. 2017 Spring;11(2):69-77.
A tumefactive lesion of central nervous system (CNS) is defined as a mass-like lesion with a size greater than 2 cm in brain detected by magnetic resonance imaging (MRI). Neuroimaging may help to distinguish the nature of a tumefactive lesion and therefore, can prevent an unnecessary brain biopsy. Here we emphasized on determining the nature of a CNS tumefactive lesions with the help of MRI and more explanations about demyelinating lesions with focus on Schilder and Balo diseases as two multiple sclerosis variants. We have reported here two boys of 10 and 8 years of age respectively of multiple sclerosis (MS) variants who presented with acute neurologic complications to our hospital as one of the two referral children hospital in Tehran, Iran. Tumefactive demyelinating lesions can be considered a separate entity that itself can contain Schilder disease, Balo disease, some cases of acute disseminated encephalomyelitis (ADEM) or classic MS. MRI can help to establish a diagnosis of a tumefactive lesion and to differentiate among different underlying etiologies.
中枢神经系统（CNS）的肿胀性病变被定义为通过磁共振成像（MRI）在脑中检测到的大小大于2 cm的肿块样病变。神经影像学有助于区分肿胀性病变的性质，因此可以避免不必要的脑活检。在此，我们着重借助MRI确定CNS肿胀性病变的性质，并更多地解释脱髓鞘病变，重点关注作为两种多发性硬化症变体的席尔德病和巴洛病。我们在此报告了两名分别为10岁和8岁的男孩，他们患有多发性硬化症（MS）变体，作为伊朗德黑兰两家转诊儿童医院之一，他们因急性神经系统并发症前来我院就诊。肿胀性脱髓鞘病变可被视为一个单独的实体，其本身可能包含席尔德病、巴洛病、一些急性播散性脑脊髓炎（ADEM）病例或经典型MS。MRI有助于确立肿胀性病变的诊断，并区分不同的潜在病因。
