Özdaş Sabri, Olt Serdar, Şirik Mehmet
Adıyaman University Medical Faculty, Department of General Surgery, Adıyaman, Turkey.
Adıyaman University Medical Faculty, Department of Internal Medicine, Adıyaman, Turkey.
Open Access Maced J Med Sci. 2017 Jun 11;5(3):316-318. doi: 10.3889/oamjms.2017.074. eCollection 2017 Jun 15.
To investigate the effect of bariatric surgery on HbA1c and serum cortisol levels in morbidly obese patients without type 2 diabetes mellitus.
Twenty-nine patients who underwent sleeve gastrectomy and whose body mass index was> 40 were included in the present study. Patients' files were reviewed retrospectively. Those with diabetes mellitus and those with age <18 were excluded from the study. Pre-operative and 1-year post operative data were documented. The obtained data were analysed by SPSS statistical program.
The mean age of the patients was 27.4 ± 8.4. 5 of the patients were male, and 24 were female. The mean body mass index of the patients was 44 ± 2.3. 1 patient [3.4%] had hypertension. Four patients [13.7%] had gastroesophageal reflux disease. The number of smokers was 7 [24.1%], and the number of alcohol users was 3 [10.3%]. There was a statistically significant decrease in HbA1c, body mass index values after operation [p value <0.01], but cortisol was not different [p value = 0.72].
In this present study we found that bariatric surgery caused a significant decrease in HbA1c levels in non-diabetic patients, suggesting that bariatric surgery may prevent Type 2 Diabetes Mellitus in obese patients.
研究减重手术对无2型糖尿病的病态肥胖患者糖化血红蛋白（HbA1c）和血清皮质醇水平的影响。
本研究纳入29例行袖状胃切除术且体重指数>40的患者。对患者病历进行回顾性分析。排除患有糖尿病和年龄<18岁的患者。记录术前和术后1年的数据。采用SPSS统计软件对所得数据进行分析。
患者的平均年龄为27.4±8.4岁。其中男性5例，女性24例。患者的平均体重指数为44±2.3。1例患者（3.4%）患有高血压。4例患者（13.7%）患有胃食管反流病。吸烟者7例（24.1%），饮酒者3例（10.3%）。术后糖化血红蛋白、体重指数值有统计学意义的下降（p值<0.01），但皮质醇无差异（p值=0.72）。
在本研究中，我们发现减重手术使非糖尿病患者的糖化血红蛋白水平显著降低，提示减重手术可能预防肥胖患者发生2型糖尿病。
