血清同型半胱氨酸与白癜风面积评分指数之间的相关性。

Correlation between Serum Homocysteine and Vitiligo Area Scoring Index.

作者信息

Hasibuan Dina R U, Putra Imam B, Jusuf Nelva K

机构信息

Dermatovenereology, Faculty of Medicine, University of Sumatera Utara, Medan, North Sumatera, Indonesia.

出版信息

Open Access Maced J Med Sci. 2017 Jun 11;5(3):332-334. doi: 10.3889/oamjms.2017.066. eCollection 2017 Jun 15.

DOI:10.3889/oamjms.2017.066

PMID:28698752

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5503732/

Abstract

BACKGROUND

Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity.

AIM

To determine correlation between serum homocysteine and vitiligo area Scoring Index (VASI).

SUBJECT AND METHOD

This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood's lamp examinations then VASI score was determined and same numbers of control. We conducted blood sampling and measurement of serum homocysteine level to the patients.

RESULTS

There is no significant correlation between serum homocysteine and VASI score (p = 0.133, r = 0.281), family history (p = 0.706), and duration of vitiligo (p = 0.993, r = 0.002). There is no significant difference between serum homocysteine in vitiligo patients and controls (p = 0.905). There is a correlation between serum homocysteine with gender (p = 0.001) and age (p = 0.036; r = 0.385) in vitiligo patient.

CONCLUSION

There is no significant correlation between serum homocysteine and VASI score, family history, and duration of vitiligo. There is no significant difference between serum homocysteine in vitiligo patients and controls. There is a correlation between serum homocysteine with gender and age in vitiligo patient.

摘要

背景

白癜风是一种慢性皮肤病。由黑素细胞破坏引起的白色斑片是其特征性表现，会影响美观。直到最近，白癜风的发病机制仍不清楚。先前的研究提到了同型半胱氨酸在白癜风中的作用，因此它有可能成为确定白癜风严重程度的生物标志物。

目的

确定血清同型半胱氨酸与白癜风面积评分指数（VASI）之间的相关性。

对象与方法

这是一项横断面分析研究，纳入了30例经临床和伍德灯检查确诊的白癜风患者，确定其VASI评分，并设置相同数量的对照组。我们对患者进行了采血并检测血清同型半胱氨酸水平。

结果

血清同型半胱氨酸与VASI评分（p = 0.133，r = 0.281）、家族史（p = 0.706）以及白癜风病程（p = 0.993，r = 0.002）之间均无显著相关性。白癜风患者与对照组的血清同型半胱氨酸水平无显著差异（p = 0.905）。白癜风患者的血清同型半胱氨酸与性别（p = 0.001）和年龄（p = 0.036；r = 0.385）之间存在相关性。