Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Australas J Dermatol. 2021 Feb;62(1):e67-e72. doi: 10.1111/ajd.13462. Epub 2020 Sep 20.
Vitiligo is a chronic depigmentary skin disorder, characterised clinically by the development of white macules and or patches caused by loss of epidermal melanocytes. S100B is a dual function protein released from epidermal melanocytes in response to injury. It considered a possible marker of disease activity in both malignant melanoma and vitiligo.
To estimate the serum level of S100B level in vitiligo patients and correlate its level with disease activity and various disease parameters.
Sixty vitiligo patients and 60 healthy volunteers as controls were included in the study. Vitiligo Area Severity Index (VASI) and Vitiligo Disease Activity (VIDA) scores were estimated for each patient. Quantitative assessment of S100B level using ELISA technique was done for all participants.
S100B level was significantly correlated with the presence of vitiligo (P = 0.01), while it showed no correlation with the disease activity using VASI or VIDA scores. As regards the receiver operating characteristic (ROC) curve analysis of S100B for diagnosis and discrimination of vitiligo, serum S100B showed area under the curve (AUC) of 0.781 with 73.3% sensitivity and 80% specificity.
The serum level of S100B was related to the presence of vitiligo, but its level did not show any relation to the disease activity using either VASI and VIDA scores or various disease parameters.
白癜风是一种慢性色素减退性皮肤病，临床上表现为表皮黑素细胞丧失导致的白色斑片或斑块。S100B 是一种双功能蛋白，在受到损伤时从表皮黑素细胞中释放出来。它被认为是恶性黑色素瘤和白癜风疾病活动的可能标志物。
评估白癜风患者血清 S100B 水平，并与疾病活动度及各种疾病参数相关联。
纳入 60 例白癜风患者和 60 例健康志愿者作为对照组。对每位患者进行白癜风面积严重程度指数（VASI）和白癜风疾病活动度（VIDA）评分。采用 ELISA 技术对所有参与者的 S100B 水平进行定量评估。
S100B 水平与白癜风的存在显著相关（P=0.01），而与 VASI 或 VIDA 评分的疾病活动度无相关性。在 S100B 用于诊断和鉴别白癜风的受试者工作特征（ROC）曲线分析中，血清 S100B 的曲线下面积（AUC）为 0.781，灵敏度为 73.3%，特异性为 80%。
S100B 血清水平与白癜风的存在有关，但与 VASI 和 VIDA 评分或各种疾病参数的疾病活动度无相关性。
