Akbarin Mohammad Mehdi, Shirdel Abbas, Bari Alireza, Mohaddes Seyedeh Tahereh, Rafatpanah Houshang, Karimani Ehsan Ghayour, Etminani Kobra, Golabpour Amin, Torshizi Reza
Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran.
Hematology Department, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciencess, Mashhad, Iran.
Blood Res. 2017 Jun;52(2):106-111. doi: 10.5045/br.2017.52.2.106. Epub 2017 Jun 22.
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the and genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL.
Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of and and the HTLV-1 PVL were measured by quantitative PCR.
Significant differences in the mean expression levels of and were observed between the two study groups (ATLL and AC, =0.014 and =0.000, respectively). In addition, the ATLL group showed a significantly higher PVL than AC (=0.000). There was a significant negative relationship between PVL and survival among all study groups (=0.047).
The HTLV-1 PVL and expression of and were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, , and may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prognosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients.
成人T细胞白血病/淋巴瘤（ATLL）是一种侵袭性恶性肿瘤，预后极差，生存期短，由1型人类嗜T淋巴细胞病毒（HTLV-1）引起。HTLV-1生物标志物反式激活因子x（TAX）和HTLV-1碱性亮氨酸拉链因子（HBZ）是主要致癌基因和危及生命的因素。本研究旨在评估 和 基因以及HTLV-1前病毒载量（PVL）在ATLL患者生存中的作用。
2011年至2015年期间对43名HTLV-1感染个体进行了评估，其中包括18名无症状携带者（AC）和25名ATLL患者（ATLL）。通过定量PCR测量 和 的mRNA表达以及HTLV-1 PVL。
两个研究组（ATLL和AC，分别为 =0.014和 =0.000）之间观察到 和 的平均表达水平存在显著差异。此外，ATLL组的PVL显著高于AC组（ =0.000）。所有研究组中PVL与生存率之间存在显著负相关（ =0.047）。
ATLL组中HTLV-1 PVL以及 和 的表达高于AC组。此外，在所有ATLL受试者中，较高的PVL与较短的生存时间相关。因此，测量PVL、 和 可能有助于监测和预测HTLV-1感染结果，PVL可能有助于评估ATLL患者的预后。本研究证明了这些病毒学标志物与ATLL患者生存率之间可能存在的相关性。
