大脑中去甲肾上腺素和5-羟色胺含量的研究——II. 巴比妥钠和氯丙嗪的作用。

Studies of contents of norepinephrine and 5-hydroxytryptamine in brain--II. Effect of sodium barbitone and chlorpromazine.

作者信息

Rahman T A, Mohamed M I, Aly M S, Moustafa S

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):159-63. doi: 10.1016/0742-8413(85)90224-5.

Abstract

The effect of i.p. injection of sodium barbitone and chlorpromazine (25 mg/100 g body wt) on the levels of NE, 5-HT and body temperature was investigated in the brain regions of the field rat and the guinea-pig. Injection of the field rat with barbitone sodium or chlorpromazine provoked a general increase in the NE and 5-HT concentrations of the various brain parts. In guinea-pig variable changes were observed. Following injection with either of the two drugs, hypothermia was induced in the two animals at all of the time intervals examined.

摘要

研究了腹腔注射巴比妥钠和氯丙嗪（25毫克/100克体重）对田鼠和豚鼠脑区去甲肾上腺素（NE）、5-羟色胺（5-HT）水平及体温的影响。给田鼠注射巴比妥钠或氯丙嗪会引起各脑区NE和5-HT浓度普遍升高。在豚鼠中观察到了不同变化。给两只动物注射这两种药物中的任何一种后，在所有检测的时间间隔内均诱发了体温过低。