有机电子生物材料的基因传递。
Gene Delivery with Organic Electronic Biomaterials.
机构信息
Department McGill Biomedical Engineering Department, Duff Medical Building, 3775 rue University, Montreal, Quebec, H3A 2B4. Canada.
Department of Chemistry and Materials Science Institute, Faraday Building, Faculty of Science and Technology, Lancaster University, Lancaster, Lancashire, LA1 4YB. United Kingdom.
出版信息
Curr Pharm Des. 2017;23(24):3614-3625. doi: 10.2174/1381612823666170710124137.
Gene therapy may be capable of treating a variety of diseases, a prerequisite of which is the successful delivery of polynucleic acids (e.g., DNA, RNA) to a patient's cells. Delivery can be achieved technologically (e.g., using electroporation), using viruses (natural gene delivery vectors) or non-viral vectors (e.g., lipids, nanoparticles, polymers). This article aims to give the reader an overview of the use of organic electronic materials (i.e., fullerenes, graphenes and conjugated polymers) as non-viral gene delivery vectors.
基因治疗可能有能力治疗多种疾病，其前提是将多核苷酸（例如 DNA、RNA）成功递送到患者的细胞中。可以通过技术手段（例如电穿孔）、病毒（天然基因传递载体）或非病毒载体（例如脂质、纳米颗粒、聚合物）来实现传递。本文旨在为读者概述有机电子材料（即富勒烯、石墨烯和共轭聚合物）作为非病毒基因传递载体的应用。
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