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刺激响应型生物材料在组织工程中的应用

Stimuli-responsive Biomaterials for Tissue Engineering Applications.

机构信息

Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University Greater Noida, Uttar Pradesh, India.

College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, India.

出版信息

Curr Pharm Biotechnol. 2024;25(8):981-999. doi: 10.2174/1389201024666230818121821.

DOI:10.2174/1389201024666230818121821
PMID:37594093
Abstract

The use of ''smart materials,'' or ''stimulus responsive'' materials, has proven useful in a variety of fields, including tissue engineering and medication delivery. Many factors, including temperature, pH, redox state, light, and magnetic fields, are being studied for their potential to affect a material's properties, interactions, structure, and/or dimensions. New tissue engineering and drug delivery methods are made possible by the ability of living systems to respond to both external stimuli and their own internal signals) for example, materials composed of stimuliresponsive polymers that self assemble or undergo phase transitions or morphology transformation. The researcher examines the potential of smart materials as controlled drug release vehicles in tissue engineering, aiming to enable the localized regeneration of injured tissue by delivering precisely dosed drugs at precisely timed intervals.

摘要

“智能材料”或“响应性材料”的使用已被证明在多个领域非常有用,包括组织工程和药物输送。许多因素,包括温度、pH 值、氧化还原状态、光和磁场,都在研究其对材料性能、相互作用、结构和/或尺寸的潜在影响。例如,由对外部刺激和自身内部信号有响应能力的刺激响应聚合物组成的材料,可以自组装或经历相转变或形态转变,这使得新的组织工程和药物输送方法成为可能。研究人员研究了智能材料作为组织工程中控制药物释放载体的潜力,旨在通过在精确的时间间隔内精确剂量给药来实现受损组织的局部再生。

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