Mohammadinejad Reza, Dadashzadeh Arezoo, Moghassemi Saeid, Ashrafizadeh Milad, Dehshahri Ali, Pardakhty Abbas, Sassan Hosseinali, Sohrevardi Seyed-Mojtaba, Mandegary Ali
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
J Adv Res. 2019 Jan 18;18:81-93. doi: 10.1016/j.jare.2019.01.004. eCollection 2019 Jul.
Recently, carbon dots (CDs) have attracted great attention due to their superior properties, such as biocompatibility, fluorescence, high quantum yield, and uniform distribution. These characteristics make CDs interesting for bioimaging, therapeutic delivery, optogenetics, and theranostics. Photoluminescence (PL) properties enable CDs to act as imaging-trackable gene nanocarriers, while cationic CDs with high transfection efficiency have been applied for plasmid DNA and siRNA delivery. In this review, we have highlighted the precursors, structure and properties of positively charged CDs to demonstrate the various applications of these materials for nucleic acid delivery. Additionally, the potential of CDs as trackable gene delivery systems has been discussed. Although there are several reports on cellular and animal approaches to investigating the potential clinical applications of these nanomaterials, further systematic multidisciplinary approaches are required to examine the pharmacokinetic and biodistribution patterns of CDs for potential clinical applications.
近年来，碳点（CDs）因其优异的性能，如生物相容性、荧光性、高量子产率和均匀分布等，而备受关注。这些特性使得碳点在生物成像、治疗递送、光遗传学和诊疗学等领域具有吸引力。光致发光（PL）特性使碳点能够作为可成像追踪的基因纳米载体，而具有高转染效率的阳离子碳点已被应用于质粒DNA和小干扰RNA（siRNA）的递送。在本综述中，我们重点介绍了带正电荷碳点的前体、结构和性质，以展示这些材料在核酸递送方面的各种应用。此外，还讨论了碳点作为可追踪基因递送系统的潜力。尽管有几篇关于细胞和动物研究这些纳米材料潜在临床应用的报道，但仍需要进一步系统的多学科方法来研究碳点在潜在临床应用中的药代动力学和生物分布模式。
