Lin Hsien-Feng, Liao Kuan-Fu, Chang Ching-Mei, Lin Cheng-Li, Lai Shih-Wei
a School of Chinese Medicine , China Medical University , Taichung , Taiwan.
b Department of Family Medicine , China Medical University Hospital , Taichung , Taiwan.
Curr Med Res Opin. 2017 Dec;33(12):2235-2240. doi: 10.1080/03007995.2017.1354831. Epub 2017 Aug 10.
BACKGROUND/OBJECTIVE: Potential association between prior statin use and chronic osteomyelitis is examined.
A nationwide case-control study was conducted based on data taken from the Taiwan National Health Insurance program. The case group includes 2338 subjects aged 20-84 years newly diagnosed for chronic osteomyelitis from 2000 to 2013; the control group included 2338 randomly selected subjects without chronic osteomyelitis matched for sex, age, and index year. Statin use was respectively defined as "current", "recent" or "past" if the most recent statin prescription was filled <3 months, 3-6 months or ≥6 months prior to the chronic osteomyelitis diagnosis. Relative risk of chronic osteomyelitis associated with statin use was measured by the odds ratio (OR) with 95% confidence interval (CI) using the conditional logistic regression model.
After controlling for potential confounders, the adjusted ORs of chronic osteomyelitis were 0.57 for subjects with current statin use (95% CI 0.45, 0.72), 0.80 for subjects with recent statin use (95% CI 0.48, 1.33), and 1.00 for subjects with past statin use (95% CI 0.83, 1.20), compared patients with no prior statin use. In further analysis, the adjusted ORs of chronic osteomyelitis were 0.70 for subjects with cumulative statin use <12 months (95% CI 0.47, 1.07), and 0.56 for subjects with cumulative statins use ≥12 months (95% CI 0.41, 0.77), compared with those with no prior statin use.
Current statin use is associated with reduced concurrent diagnosis of chronic osteomyelitis, particularly for a cumulative statin use ≥12 months.
背景/目的：研究既往使用他汀类药物与慢性骨髓炎之间的潜在关联。
基于台湾国民健康保险计划的数据进行了一项全国性病例对照研究。病例组包括2000年至2013年新诊断为慢性骨髓炎的2338名年龄在20 - 84岁的受试者；对照组包括2338名随机选取的无慢性骨髓炎的受试者，这些受试者在性别、年龄和索引年份上进行了匹配。如果在慢性骨髓炎诊断前最近一次他汀类药物处方的取药时间<3个月、3 - 6个月或≥6个月，则他汀类药物的使用分别定义为“当前”、“近期”或“过去”。使用条件逻辑回归模型，通过比值比（OR）及95%置信区间（CI）来衡量与他汀类药物使用相关的慢性骨髓炎的相对风险。
在控制了潜在混杂因素后，与未使用过他汀类药物的患者相比，当前使用他汀类药物的受试者慢性骨髓炎的调整后OR为0.57（95% CI 0.45, 0.72），近期使用他汀类药物的受试者为0.80（95% CI 0.48, 1.33），过去使用他汀类药物的受试者为1.00（95% CI 0.83, 1.20）。在进一步分析中，与未使用过他汀类药物的受试者相比，累积使用他汀类药物<12个月的受试者慢性骨髓炎的调整后OR为0.70（95% CI 0.47, 1.07），累积使用他汀类药物≥12个月的受试者为0.56（95% CI 0.41, 0.77）。
当前使用他汀类药物与慢性骨髓炎的并发诊断减少相关，尤其是累积使用他汀类药物≥12个月时。
