Center S A, Baldwin B H, Dillingham S, Erb H N, Tennant B C
J Am Vet Med Assoc. 1986 Mar 1;188(5):507-10.
The diagnostic value of serum gamma-glutamyl transferase (GGT) activity and serum alkaline phosphatase (ALP) activity in the detection of liver disease in the cat (n = 69) was compared. On the basis of histologic examination of the liver, cats were assigned to 8 groups: group 1--complete extrahepatic bile duct obstruction (n = 5), group 2--cholangiohepatitis-cholangitis syndrome (n = 11), group 3--hepatic lipidosis (n = 15), group 4--neoplasia, including lymphosarcoma and myeloproliferative disease (n = 9), group 5--hepatic necrosis (n = 7), group 6--cirrhosis (n = 3), group 7--portosystemic vascular anomaly (n = 4), and group 8--miscellaneous (n = 15). Cats assigned to group 8 lacked substantial histologic abnormalities of the liver. The mean value +/- SD of GGT in 20 clinically normal cats was 0.44 +/- 0.26 IU/L. The highest GGT activity in clinical patients developed in groups 1, 2, and 6. The highest ALP activity developed in groups 1 to 4. Significant correlations between GGT and ALP activities were detected only in groups 2 (P less than 0.001) and 5 (P less than 0.10). Among 54 cats with hepatic disease, only 11% had both the GGT and ALP activities within the normal ranges. Comparatively, 52% had ALP activities within the normal range, and 17% had GGT activities within the normal range.(ABSTRACT TRUNCATED AT 250 WORDS)
比较了血清γ-谷氨酰转移酶（GGT）活性和血清碱性磷酸酶（ALP）活性对猫（n = 69）肝病检测的诊断价值。根据肝脏组织学检查，将猫分为8组：第1组——完全肝外胆管阻塞（n = 5），第2组——胆管肝炎-胆管炎综合征（n = 11），第3组——肝脂肪变性（n = 15），第4组——肿瘤，包括淋巴肉瘤和骨髓增殖性疾病（n = 9），第5组——肝坏死（n = 7），第6组——肝硬化（n = 3），第7组——门体循环血管异常（n = 4），第8组——其他（n = 15）。分配到第8组的猫肝脏缺乏明显的组织学异常。20只临床正常猫的GGT平均值±标准差为0.44±0.26 IU/L。临床患者中GGT活性最高出现在第1、2和6组。ALP活性最高出现在第1至4组。仅在第2组（P < 0.001）和第5组（P < 0.10）中检测到GGT和ALP活性之间存在显著相关性。在54只患有肝病的猫中，只有11%的GGT和ALP活性均在正常范围内。相比之下，52%的猫ALP活性在正常范围内，17%的猫GGT活性在正常范围内。（摘要截断于250字）
