From the Department of Preventive Medicine (Shimanoe, Hara, Nishida, Horita, Tanaka), Faculty of Medicine, Saga University, Saga; Department of Public Health (Nanri), Showa University School of Medicine; Department of Nutritional Science (Yamada), National Institute of Health and Nutrition, Tokyo; Department of Environmental Oncology (Li, Kasai, Kawai), Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu; and Laboratory of Exercise Physiology (Higaki), Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan.
Psychosom Med. 2018 Jan;80(1):28-33. doi: 10.1097/PSY.0000000000000513.
Psychosocial stress may influence the risk of disease through its association with oxidative DNA damage. We examined whether perceived stress and depressive symptoms were associated with urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), with mutual interaction on 8-OHdG.
This cross-sectional study included 6517 individuals aged 45 to 74 years who participated, between 2010 and 2012, in a follow-up survey of an ongoing cohort study. Perceived stress during the past year was measured using a self-report questionnaire. Depressive symptoms were evaluated using the Zung Self-Rating Depression Scale. Urinary 8-OHdG concentrations were measured using a column switching high-pressure liquid chromatography system coupled to an electrochemical detector.
Higher perceived stress was significantly associated with higher 8-OHdG (2.1% increase per one-category increase of stress; ptrend = .025), even after adjusting for sex, age, supplement use, psychosocial factors, psychotropic medication use, smoking, and body mass index. This association was modestly attenuated after further adjustment for physical activity, suggesting possible mediation or confounding by this factor. Depressive symptoms were not significantly associated with 8-OHdG. No significant interaction was detected between perceived stress and depressive symptoms on 8-OHdG.
In a general Japanese population, we found a weak positive association between perceived stress and urinary excretion of 8-OHdG, whereas no association was observed between depressive symptoms and 8-OHdG. Further studies are needed to examine whether the association between perceived stress and 8-OHdG is modified by depressive symptoms.
心理社会压力可能会通过与氧化 DNA 损伤的关联影响疾病风险。我们研究了感知压力和抑郁症状是否与尿 8-羟基脱氧鸟苷（8-OHdG）的排泄有关，以及它们是否存在 8-OHdG 的相互作用。
本横断面研究纳入了 6517 名年龄在 45 至 74 岁之间的个体，他们于 2010 年至 2012 年期间参加了一项正在进行的队列研究的随访调查。过去一年的感知压力使用自我报告问卷进行测量。抑郁症状使用zung 自评抑郁量表进行评估。尿 8-OHdG 浓度使用柱切换高压液相色谱系统与电化学检测器联用进行测量。
感知压力越高，8-OHdG 浓度越高（压力每增加一个等级，8-OHdG 增加 2.1%；ptrend =.025），即使在校正了性别、年龄、补充剂使用、心理社会因素、精神药物使用、吸烟和体重指数后也是如此。进一步调整体力活动后，这种关联略有减弱，表明该因素可能存在中介或混杂作用。抑郁症状与 8-OHdG 无显著相关性。感知压力和抑郁症状对 8-OHdG 无显著交互作用。
在日本一般人群中，我们发现感知压力与尿 8-OHdG 排泄之间存在微弱的正相关，而抑郁症状与 8-OHdG 之间无相关性。需要进一步研究以检验感知压力与 8-OHdG 之间的关联是否受抑郁症状的影响。
