Department of Epidemiology and International Health, International Clinical Research Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
Psychiatry Res. 2012 Dec 30;200(2-3):318-22. doi: 10.1016/j.psychres.2012.05.035. Epub 2012 Jun 23.
We sought to explore the relationship between depressive symptoms and urinary 8-hydroxydeoxyguanine (8-OHdG), a biomarker of systemic oxidative DNA damage and repair, among 301 men and 210 women aged 21-67 years working in two municipal offices. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression scale (CES-D). The geometric mean and its 95% confidence interval (CI) of urinary 8-OHdG concentrations were calculated according to the quartile of CES-D score. The prevalence of depressive symptoms, defined as having CES_D of ≥16, was 35.9% in men and 35.2% in women. There was no significant difference in geometric mean of urinary 8-OHdG concentrations according to the levels of depressive symptoms. In men, the multivariable-adjusted geometric mean of urinary 8-OHdG concentrations (95% CIs) in the first, second, third, and fourth category of depressive symptoms was 1.09 (1.02-1.16), 1.16 (1.08-1.24), 1.15 (1.07-1.24), and 1.10 (1.02-1.18), respectively (p for trend=0.86). Similarly, no significant association was found in the analyses among women, nonsmoking men, and smoking men. The lack of association between depressive symptoms and urinary 8-OHdG concentrations may indicate the absence or more complex interactions between milder forms of depression and systemic oxidative DNA damage and repair in well-functioning population.
我们试图探讨抑郁症状与尿 8-羟基脱氧鸟苷（8-OHdG）之间的关系，8-OHdG 是一种系统性氧化 DNA 损伤和修复的生物标志物，研究对象为在两个市政办公室工作的 301 名男性和 210 名 21-67 岁的女性。抑郁症状使用流行病学研究中心抑郁量表（CES-D）进行评估。根据 CES-D 评分的四分位距计算尿 8-OHdG 浓度的几何均数及其 95%置信区间（CI）。定义 CES-D≥16 为存在抑郁症状，男性和女性的抑郁症状患病率分别为 35.9%和 35.2%。根据抑郁症状的严重程度，尿 8-OHdG 浓度的几何均数没有显著差异。在男性中，抑郁症状第一、二、三、四级别的尿 8-OHdG 浓度的多变量调整后几何均数（95%CI）分别为 1.09（1.02-1.16）、1.16（1.08-1.24）、1.15（1.07-1.24）和 1.10（1.02-1.18）（趋势检验 p=0.86）。同样，在女性、不吸烟男性和吸烟男性中，也未发现分析存在显著相关性。抑郁症状与尿 8-OHdG 浓度之间缺乏关联可能表明，在功能良好的人群中，轻度抑郁与系统性氧化 DNA 损伤和修复之间不存在关联，或者存在更复杂的相互作用。
