Razi Bahman, Alizadeh Shahab, Omidkhoda Azadeh, Imani Danyal, Rezaei Ramazan
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box. 14155-6117, Tehran, Iran.
Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S939-S947. doi: 10.1016/j.dsx.2017.07.020. Epub 2017 Jul 3.
Observational studies evaluating the association between chronic hepatitis B (CHB) and risk of metabolic syndrome (MetS) have yielded inconclusive results.
The current meta-analysis was conducted to identify whether CHB infection plays a role in the risk of MetS and its components.
The electronic search of MEDLINE, PubMed Central, and EMBASE databases was systematically performed from their inception until February 2017 to identify all eligible studies. The most adjusted risk estimates and their corresponding 95% confidence intervals (CIs) for the associations of chronic hepatitis B with MetS and its components were collected and analyzed.
A total of 13 studies, with a total sample size of 138,994,999 subjects and 35,481,231 individuals with MetS were included in this Meta-analysis. The results of pooled analysis revealed that CHB infection is related to reduced risk of MetS (OR=0.83, 95%CI=0.71-0.79, random effects), with evidence of significant heterogeneity (I2=89%, P<0.001). This association was an age, gender, and ethnicity-dependent relationship. Moreover, CHB was associated with reduced risk of elevated blood pressure, reduced HDL-cholesterol, increased fasting glucose, and, most strongly with increased triglycerides in some subgroups. The sensitivity analyses confirmed the stability of the results.
This meta-analysis suggests that CHB is associated with decreased risk of MetS and some of its single components.
评估慢性乙型肝炎（CHB）与代谢综合征（MetS）风险之间关联的观察性研究结果尚无定论。
进行当前的荟萃分析，以确定CHB感染是否在MetS及其组分的风险中起作用。
系统检索MEDLINE、PubMed Central和EMBASE数据库，从建库至2017年2月，以识别所有符合条件的研究。收集并分析慢性乙型肝炎与MetS及其组分关联的最具调整性的风险估计值及其相应的95%置信区间（CI）。
本荟萃分析共纳入13项研究，总样本量为138,994,999名受试者，其中35,481,231名患有MetS。汇总分析结果显示，CHB感染与MetS风险降低相关（OR=0.83，95%CI=0.71-0.79，随机效应），有显著异质性证据（I2=89%，P<0.001）。这种关联是年龄、性别和种族依赖性关系。此外，在一些亚组中，CHB与血压升高风险降低、高密度脂蛋白胆固醇降低、空腹血糖升高风险降低相关，与甘油三酯升高关联最强。敏感性分析证实了结果的稳定性。
本荟萃分析表明，CHB与MetS及其一些单一组分的风险降低相关。
